The film begins when Brainy Indy (Kim Chiu), MVP MJ2 (Gerald Anderson), Sosy Pre (Maja Salvador), Rebel Gael (Geoff Eigenmann) and Nice Guy Nathan (Jason Abalos) are college freshmen who enter FDH University, until they all got involved in the biggest mystery the university has ever encountered- the Basketball Water Contamination Accident. Initial investigation shows that the water drank by the players during the game was contaminated by a mysterious substance. The first investigation begins with Indy, then to MJ2, Pré and Gael, when they discovered that the culprit is from the same school. Nathan, when investigated is proven the culprit. And, before being expelled from school, was saved by his friends, whom he indirectly help, as told from their story: Indy created the substance, an Anti-love potion for MJ2, who was the target of Gael when bribed by several criminals, which Pré has somewhat a relationship, and Nathan, trying to help them from their mischief and problems. After the case is closed, Nathan is not expelled and instead Nathan is in community service. But because of his popularity, attitude and honesty,all of the students helped Nathan during community service.